In this blog post we will explore how common psychiatric medications work. We will explore this by breaking down the common of class of medications used to treatment common psychiatric conditions. We will also explore the common myths associated with taking a psychiatric medication.

Medications for Depression

Antidepressants are a class of medication used to treat depression, anxiety, and other mental health conditions. They work by affecting the levels of certain chemicals in the brain called neurotransmitters. These chemicals are responsible for transmitting messages between nerve cells in the brain, and imbalances or deficiencies in certain neurotransmitters have been linked to mood disorders.

The most commonly targeted neurotransmitters by antidepressants are serotonin, norepinephrine, and dopamine. Here’s a breakdown of how antidepressants affect each of these neurotransmitters:

Serotonin: Many antidepressants work by increasing the availability of serotonin in the brain. Serotonin is a neurotransmitter that helps regulate mood, appetite, and sleep. Low levels of serotonin have been linked to depression and anxiety. Antidepressants that target serotonin include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and atypical antidepressants.

SSRIs work by blocking the reabsorption of serotonin in the brain, which allows more of the neurotransmitter to remain in the brain and enhance its effects. SNRIs work similarly to SSRIs, but also block the reabsorption of norepinephrine, another neurotransmitter that is involved in regulating mood.

Norepinephrine: Norepinephrine is another neurotransmitter that is involved in regulating mood, attention, and arousal. Antidepressants that target norepinephrine include SNRIs, tricyclic antidepressants (TCAs), and atypical antidepressants.

SNRIs work by blocking the reabsorption of both serotonin and norepinephrine, which allows more of these neurotransmitters to remain in the brain and enhance their effects. TCAs also work by blocking the reabsorption of norepinephrine and serotonin, but are not used as frequently as they have more side effects. Atypical antidepressants can also affect norepinephrine levels in the brain, but do not specifically target this neurotransmitter.

Dopamine: Dopamine is a neurotransmitter that is involved in regulating motivation, reward, and pleasure. Antidepressants that target dopamine include atypical antidepressants and monoamine oxidase inhibitors (MAOIs).

Atypical antidepressants can increase the availability of dopamine in the brain, which can help improve mood and motivation. MAOIs work by blocking an enzyme called monoamine oxidase, which breaks down neurotransmitters like dopamine, serotonin, and norepinephrine.

Antidepressants work by affecting the levels of certain neurotransmitters in the brain, including serotonin, norepinephrine, and dopamine. By enhancing the effects of these neurotransmitters, antidepressants can help improve mood, reduce anxiety, and manage other symptoms of mental health conditions. It is important to work with a healthcare provider to determine the right medication and dosage for you, as well as to monitor for potential side effects.

Medications for Focus

ADHD, or attention deficit hyperactivity disorder, is a neurodevelopmental disorder that affects both children and adults. It is characterized by symptoms such as difficulty concentrating, impulsivity, and hyperactivity. While behavioral therapy can be effective in managing these symptoms, medication is often prescribed as a first-line treatment for ADHD. The most commonly prescribed medications for ADHD are stimulants, which include medications like methylphenidate (Ritalin) and amphetamine (Adderall). Here’s how these medications work:

Stimulating the central nervous system: Stimulant medications work by increasing the levels of certain neurotransmitters in the brain, including dopamine and norepinephrine. These neurotransmitters are involved in regulating attention, motivation, and arousal. By increasing the levels of these neurotransmitters, stimulants can help improve concentration and reduce impulsivity and hyperactivity.
Improving brain function: ADHD is associated with lower levels of activity in certain parts of the brain that are involved in regulating attention and controlling impulses. Stimulant medications can help increase activity in these regions, which can improve cognitive function and help individuals with ADHD focus better.
Adjusting brain chemistry: While the exact mechanism of how stimulants work is not completely understood, it is thought that they may help adjust the balance of neurotransmitters in the brain. This can help individuals with ADHD feel more alert and focused, while also reducing their impulsivity and hyperactivity.

It is important to note that while stimulant medications can be effective in managing symptoms of ADHD, they do come with potential side effects. These can include appetite suppression, difficulty sleeping, and increased heart rate and blood pressure. Additionally, stimulants can be habit-forming, so it is important to work with a healthcare provider to determine the right medication and dosage for you, as well as to monitor for potential side effects. Non-stimulant medications are also available for ADHD, and work by affecting different neurotransmitters in the brain. These include medications like atomoxetine (Strattera) and guanfacine (Intuniv).

Medications for Mood Stabilization

Mood stabilizers are a class of medication commonly used to treat bipolar disorder, a mental health condition characterized by episodes of mania and depression. Mood stabilizers work by regulating the levels of certain chemicals in the brain, including neurotransmitters and ions, that play a role in mood regulation. Here are some of the ways in which mood stabilizers work:

Modulating neurotransmitters: Neurotransmitters are chemicals in the brain that transmit signals between nerve cells. Abnormalities in neurotransmitter levels have been linked to mood disorders, including bipolar disorder. Mood stabilizers work by modulating the levels of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are involved in regulating mood, motivation, and pleasure.
Regulating ion channels: Mood stabilizers can also work by regulating ion channels in the brain, specifically those that control the flow of ions such as sodium, potassium, and calcium. This can help to stabilize the electrical activity in the brain, which can help to improve mood and reduce symptoms of mania and depression.
Protecting neurons: Mood stabilizers can also help to protect neurons in the brain from damage and cell death. This is thought to be due to their ability to increase the production of certain proteins that promote neuronal growth and survival.
Reducing inflammation: Inflammation has been linked to mood disorders such as bipolar disorder. Mood stabilizers can help to reduce inflammation in the brain, which may contribute to their ability to improve mood and reduce symptoms of mania and depression.

Examples of mood stabilizers include lithium, valproic acid, carbamazepine, and lamotrigine. These medications are often used in combination with other medications, such as antipsychotics or antidepressants, to help manage symptoms of bipolar disorder. It is important to work with a healthcare provider to determine the right medication and dosage for you, as well as to monitor for potential side effects.

Greg Roussett NP is a board certified psychiatric mental health nurse practitioner offering treatment for anxiety, depression, and mood disorders. He is a cognitive behavioral therapist, psychopharmacologist (prescribing practices similar to a psychiatrist ), and offers a combination of psychotherapy and medication management to individuals experiencing depression. His office is located in Rockridge in Oakland, CA and provides services across the bay area to those residing in cities inclusive of Piedmont, Lafayette, Walnut Creek, Berkeley, and San Francisco. One of his primary specialties is psychopharmacology. To book a free consultation, click here.